QY research recently published the current situation and future development trend of China's deuterated solvent market from 2021 to 2027. The report covers a comprehensive analysis of the deuterated solvent industry, focusing on the key factors affecting its development. The report is based on primary and secondary research methods, which produce historical and forecast data. It provides the main statistical data about the current situation of the industry, which is a valuable guidance and direction for companies and individuals interested in the market.
Deuterated reagent chemicals are derived from nuclear physics and heavy water refining industry. The advent of the atomic bomb in the 1940s promoted the rapid development of seawater and heavy water refining industry, and gradually shifted from military and national defense to high-tech R & D applications. Nuclear magnetic resonance instruments need to use a large number of deuterated reagents, which are used to avoid the interference of hydrogen atoms in ordinary solvents, so as to accurately analyze the proportion of organic molecular hydrogen elements.
Deuterated reagent chemicals are derivatives first discovered in the extraction of heavy water in nuclear physics. With the improvement of the industrial capacity of extracting heavy water, the extraction cost of deuterated chemicals is getting lower and lower, and gradually changed from military industry to civil high-tech, and then widely used in ordinary industry. Deuterated reagent chemicals are widely used in nuclear magnetic resonance analysis, mainly to lock deuterons, avoid the interference of hydrogen atoms in ordinary solvents, prevent magnetic field drift and shimming, and observe the role of fine structure (coupling splitting) of hydrogen spectrum, so as to accurately analyze the proportion of hydrogen elements in organic molecules. Deuterated compounds are a kind of important high value-added chemicals. In addition to being widely used as solvents in the field of nuclear magnetic resonance spectroscopy, they also have important applications in exploring drug metabolism, revealing organic reaction mechanism and improving material properties. The advent of the atomic bomb in the 1940s unexpectedly promoted the development of a basic industry, which is the seawater and heavy water refining industry. Later, with the transformation of this technology from military industry and national defense to high-tech R & D and application, deuterated reagent chemicals were derived. Subsequently, more and more countries began to compete to master this process, and this technology is also one of the core technologies developed by various countries. However, up to now, the production technology of high-purity deuterated derivatives is mainly mastered by Europe and the United States. Due to the high technical threshold of deuterated reagent, the domestic deuterated reagent industry has just begun to develop. The market concentration is high, mainly occupied by Cambridge isotope, Merck, Nanjing haolv biotechnology and Ningbo Cuiying chemical.
In 2020, China's deuterated solvent market reached 75 million yuan, which is expected to reach 481 million yuan in 2027, and the compound annual growth rate (CAGR) in the next few years is 26.11% (2021-2027).
This report studies the production, consumption, import and export of deuterated solvents in the Chinese market, focuses on global and local deuterated solvent manufacturers which play an important role in the Chinese market, and presents the key indicators of deuterated solvent sales, revenue, price, gross profit margin, market share and so on. This paper also studies the deuterated solvent production capacity, sales volume, revenues and market share of Chinese local manufacturers. In addition, this paper also makes an in-depth analysis on the subdivision growth of deuterated solvent products themselves, such as different deuterated solvent product types, prices, sales volume and revenue, and the market sales volume of different applications of deuterated solvents.

Heavy water can be produced in many ways. The original method was electrolysis, because heavy water could not be electrolyzed, so it could be separated from ordinary water. Another simple method is to use the boiling point of heavy water higher than that of ordinary water through repeated distillation. Later, some other better methods were developed.

Heavy water and deuterium are valuable tracer materials in the study of chemical and physiological changes. For example, if trees are irrigated with dilute heavy water, it can be measured that water can run more than ten meters to tens of meters per hour in these plants. The deuterium content in urine of people who have drunk a lot of dilute heavy water is determined.

Deuterium gas is widely used. It is not only used in nuclear energy, controllable nuclear fusion reaction, lasers, light bulbs, experimental research, semiconductor material toughening treatment, nuclear medicine and agriculture, but also has some important military applications, such as manufacturing hydrogen bombs, neutron bullets and DF laser weapons.

Deuterium oxide is a compound composed of deuterium and oxygen, also known as deuterium oxide. Its molecular formula is D2O, with a relative molecular weight of 20.0275, which is about 11% higher than the relative molecular weight of water (H2O) of 18.0153, so it is called heavy water.

In 1910, the British chemist Soddy put forward a hypothesis that there are variants of chemical elements with different relative atomic mass and radioactivity but the same physical and chemical properties. These variants should be in the same position of the periodic table, called isotopes.

As we all know, methanol is the simplest saturated monohydric alcohol with the structural formula of CH3OH. It is also called "xylol" or "Xylin" because it is first found in dry distillation wood. However, only about 1kg of methanol can be obtained by decomposing and distilling 60~80kg wood

Deuterium is a stable isotope of hydrogen and exists as deuterium gas at room temperature. It is a colorless, odorless, non-toxic and harmless flammable gas. The discovery of deuterium gas also won the Nobel Prize in chemistry.

Isotope, the English name isotope, means that different atoms of the same element with the same number of protons but different numbers of neutrons are called isotopes.

China's national conditions decide to use deuterization to improve pharmacokinetics for micro innovation, or even just to avoid the pure imitation of the original patent, which significantly reduces the difficulty. Therefore, it is easy to understand that under the premise of obvious "pure imitation" space, the reserve amount and abundance of existing important deuterated molecules, as well as the ability to quickly promote commercialization, will also become one of the important factors reflecting the competitiveness of independent deuterated enterprises. At the same time, promoting multiple pipelines and making use of comprehensive advantages to quickly commercialize operation is undoubtedly the best thing for the most leading pharmaceutical enterprises. However, once this approach is followed up to strengthen intellectual property protection in China, it may face patent risk.
The second obstacle faced by deuterated technology in practical application is the confidentiality of synthetic methods. For the preparation of deuterium labeled compounds, a relatively complete technology and product chain has been formed abroad. However, due to technical confidentiality and product monopoly, not only the technical documents and patents on synthesis are rarely published, but also the relevant technical standards and detection methods are rarely published.
The third obstacle faced by deuterated technology in practical application is related to the incompleteness of China's deuterated industry chain, mainly for China's independent deuterated drug enterprises. At present, the domestic deuterated compound synthesis technology is backward, and most deuterated reagents (such as deuterium water, deuterium gas, deuterated methanol and other basic raw materials) still rely on imports. The cost of deuterated API is high, which has become a key bottleneck restricting the R & D and industrialization of deuterated drugs in China. For example, deuterated drugs have no obvious advantages compared with the original drugs (such as improvement in effective dose, administration frequency, scope of indications, safety, etc.), and it will be more difficult for deuterated drugs to obtain better market returns after the expiration of the patent of the original drugs and the introduction of generic drugs to the market. In the follow-up, paying attention to the development of independent deuterated compound synthesis technology, promoting the industrial production of commonly used deuterated reagents, especially deuterated water, so that Chinese enterprises can prepare deuterated drugs with relatively cheap deuterated raw materials as deuterium source, which will become one of the key elements for the success of China's deuterated drug industry.