Research and development trend, challenge and investment strategy of deuterated drugs
- Categories:Technology
- Author:
- Origin:
- Time of issue:2022-03-11
(Summary description)China's national conditions decide to use deuterization to improve pharmacokinetics for micro innovation, or even just to avoid the pure imitation of the original patent, which significantly reduces the difficulty. Therefore, it is easy to understand that under the premise of obvious "pure imitation" space, the reserve amount and abundance of existing important deuterated molecules, as well as the ability to quickly promote commercialization, will also become one of the important factors reflecting the competitiveness of independent deuterated enterprises. At the same time, promoting multiple pipelines and making use of comprehensive advantages to quickly commercialize operation is undoubtedly the best thing for the most leading pharmaceutical enterprises. However, once this approach is followed up to strengthen intellectual property protection in China, it may face patent risk. The second obstacle faced by deuterated technology in practical application is the confidentiality of synthetic methods. For the preparation of deuterium labeled compounds, a relatively complete technology and product chain has been formed abroad. However, due to technical confidentiality and product monopoly, not only the technical documents and patents on synthesis are rarely published, but also the relevant technical standards and detection methods are rarely published. The third obstacle faced by deuterated technology in practical application is related to the incompleteness of China's deuterated industry chain, mainly for China's independent deuterated drug enterprises. At present, the domestic deuterated compound synthesis technology is backward, and most deuterated reagents (such as deuterium water, deuterium gas, deuterated methanol and other basic raw materials) still rely on imports. The cost of deuterated API is high, which has become a key bottleneck restricting the R & D and industrialization of deuterated drugs in China. For example, deuterated drugs have no obvious advantages compared with the original drugs (such as improvement in effective dose, administration frequency, scope of indications, safety, etc.), and it will be more difficult for deuterated drugs to obtain better market returns after the expiration of the patent of the original drugs and the introduction of generic drugs to the market. In the follow-up, paying attention to the development of independent deuterated compound synthesis technology, promoting the industrial production of commonly used deuterated reagents, especially deuterated water, so that Chinese enterprises can prepare deuterated drugs with relatively cheap deuterated raw materials as deuterium source, which will become one of the key elements for the success of China's deuterated drug industry.
Research and development trend, challenge and investment strategy of deuterated drugs
(Summary description)China's national conditions decide to use deuterization to improve pharmacokinetics for micro innovation, or even just to avoid the pure imitation of the original patent, which significantly reduces the difficulty. Therefore, it is easy to understand that under the premise of obvious "pure imitation" space, the reserve amount and abundance of existing important deuterated molecules, as well as the ability to quickly promote commercialization, will also become one of the important factors reflecting the competitiveness of independent deuterated enterprises. At the same time, promoting multiple pipelines and making use of comprehensive advantages to quickly commercialize operation is undoubtedly the best thing for the most leading pharmaceutical enterprises. However, once this approach is followed up to strengthen intellectual property protection in China, it may face patent risk.
The second obstacle faced by deuterated technology in practical application is the confidentiality of synthetic methods. For the preparation of deuterium labeled compounds, a relatively complete technology and product chain has been formed abroad. However, due to technical confidentiality and product monopoly, not only the technical documents and patents on synthesis are rarely published, but also the relevant technical standards and detection methods are rarely published.
The third obstacle faced by deuterated technology in practical application is related to the incompleteness of China's deuterated industry chain, mainly for China's independent deuterated drug enterprises. At present, the domestic deuterated compound synthesis technology is backward, and most deuterated reagents (such as deuterium water, deuterium gas, deuterated methanol and other basic raw materials) still rely on imports. The cost of deuterated API is high, which has become a key bottleneck restricting the R & D and industrialization of deuterated drugs in China. For example, deuterated drugs have no obvious advantages compared with the original drugs (such as improvement in effective dose, administration frequency, scope of indications, safety, etc.), and it will be more difficult for deuterated drugs to obtain better market returns after the expiration of the patent of the original drugs and the introduction of generic drugs to the market. In the follow-up, paying attention to the development of independent deuterated compound synthesis technology, promoting the industrial production of commonly used deuterated reagents, especially deuterated water, so that Chinese enterprises can prepare deuterated drugs with relatively cheap deuterated raw materials as deuterium source, which will become one of the key elements for the success of China's deuterated drug industry.
- Categories:Technology
- Time of issue:2022-03-11
- Views:
China's national conditions decide to use deuterization to improve pharmacokinetics for micro innovation, or even just to avoid the pure imitation of the original patent, which significantly reduces the difficulty. Therefore, it is easy to understand that under the premise of obvious "pure imitation" space, the reserve amount and abundance of existing important deuterated molecules, as well as the ability to quickly promote commercialization, will also become one of the important factors reflecting the competitiveness of independent deuterated enterprises. At the same time, promoting multiple pipelines and making use of comprehensive advantages to quickly commercialize operation is undoubtedly the best thing for the most leading pharmaceutical enterprises. However, once this approach is followed up to strengthen intellectual property protection in China, it may face patent risk.
The second obstacle faced by deuterated technology in practical application is the confidentiality of synthetic methods. For the preparation of deuterium labeled compounds, a relatively complete technology and product chain has been formed abroad. However, due to technical confidentiality and product monopoly, not only the technical documents and patents on synthesis are rarely published, but also the relevant technical standards and detection methods are rarely published.
The third obstacle faced by deuterated technology in practical application is related to the incompleteness of China's deuterated industry chain, mainly for China's independent deuterated drug enterprises. At present, the domestic deuterated compound synthesis technology is backward, and most deuterated reagents (such as deuterium water, deuterium gas, deuterated methanol and other basic raw materials) still rely on imports. The cost of deuterated API is high, which has become a key bottleneck restricting the R & D and industrialization of deuterated drugs in China. For example, deuterated drugs have no obvious advantages compared with the original drugs (such as improvement in effective dose, administration frequency, scope of indications, safety, etc.), and it will be more difficult for deuterated drugs to obtain better market returns after the expiration of the patent of the original drugs and the introduction of generic drugs to the market. In the follow-up, paying attention to the development of independent deuterated compound synthesis technology, promoting the industrial production of commonly used deuterated reagents, especially deuterated water, so that Chinese enterprises can prepare deuterated drugs with relatively cheap deuterated raw materials as deuterium source, which will become one of the key elements for the success of China's deuterated drug industry.
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